Interactions | Reactions | Processes
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Classified as: Substitution: Nucleophilic Internal
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Internal nucleophilic substitution, Sni, occurs when the initial attack produces a cyclic intermediate or an intermediate complex with tight ion-pairing. Sni is often envoked to explain the non-inversion of chiral centres.
For more information look in the Chemogenesis webbook sections on substitution reactions and substitution, transfer, abstraction, displacement (STAD).
R–OH |
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SOCl2 |
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RCl |
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RCOOH |
+ |
SOCl2 |
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RCOCl |
+ |
SO2 |
+ |
HCl |
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+ |
NaOH |
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+ |
Br– |
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+ |
H2O |
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2 |
 |
+ |
Ca(OH)2 |
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2 |
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+ |
CaCl2 |
+ |
2 |
H2O |
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2 |
 |
+ |
Ca(OH)2 |
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2 |
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+ |
CaCl2 |
+ |
2 |
H2O |
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2 |
 |
+ |
2 |
HClO |
+ |
Ca(OH)2 |
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2 |
 |
+ |
CaCl2 |
+ |
2 |
H2O |
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2 |
 |
+ |
2 |
Cl2 |
+ |
Ca(OH)2 |
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2 |
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+ |
CaCl2 |
+ |
2 |
H2O |
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 |
+ |
[OH]– |
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 |
+ |
HBr |
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© Mark R. Leach 1999 –
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