Interactions | Reactions | Processes

Classified as: Synthesis of Chloramphenicol

Starting from 4-nitroacetanilide, chloramphenicol can be made in high yield in a sequence of eight synthetic steps.
  +  
Br2
  +  
CH3COOH
         
  +  
HBr

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  +  
         

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  +  
(CH3CO)2CO
         
  +  
CH3COOH

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  +  
HCHO
         

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3
  +  
Al(OiPr)3
         
3
  +  
3

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  +  
H2O
  +  
H+(aq)
         
  +  
CH3COOH

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  +  
         
  +  

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  +  
         
  +  
CH3OH

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© Mark R. Leach 1999 –

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please contact Mark R. Leach, the author, using mark@meta-synthesis.com