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Interactions | Reactions | Processes
Classified as: Substitution: Nucleophilic Internal
Internal nucleophilic substitution, Sni, occurs when the initial attack produces a cyclic intermediate or an intermediate complex with tight ion-pairing. Sni is often envoked to explain the non-inversion of chiral centres.
For more information look in the Chemogenesis webbook sections on substitution reactions and substitution, transfer, abstraction, displacement (STAD).![](http://www.chemthes.com/mech/10.gif)
R–OH |
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SOCl2 |
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RCl |
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RCOOH |
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SOCl2 |
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RCOCl |
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SO2 |
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HCl |
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NaOH |
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Br– |
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H2O |
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2 |
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Ca(OH)2 |
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2 |
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CaCl2 |
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2 |
H2O |
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2 |
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Ca(OH)2 |
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2 |
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CaCl2 |
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2 |
H2O |
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2 |
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2 |
HClO |
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Ca(OH)2 |
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2 |
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CaCl2 |
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2 |
H2O |
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2 |
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2 |
Cl2 |
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Ca(OH)2 |
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2 |
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CaCl2 |
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H2O |
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[OH]– |
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HBr |
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© Mark R. Leach 1999 –
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