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Frequently Asked Questions

Baeyer-Villiger Reaction
The Baeyer-Villiger reactions involves the Nu attack of a protonated ketone by a per-acid: per acetic acid, CH3COOOH, or meta chloro perbenzoic acid.

The tetrahedral intermediate undergoes a 1,2-alkyl shift (rearrangement) to give the ester. The reaction can be considered as an oxygen insertion, OR an oxidation or a rearrangement.

For more information look in the Chemogenesis webbook sections on insertion reactions, redox chemistry and rearrangement reactions.