Home page
Chemogenesis web book
Chemical Thesaurus
Tutorials and Drills
Meta-Synthesis Shop
Contact Us
Links Page
Frequently Asked Questions

Hydroformylation, or the "oxo reaction", involves adding carbon monoxide and hydrogen to an alkene to give an extended carbon chain with an aldehyde terminus.

Linear aldehydes are generated over branched aldehydes.

The reaction requires high pressure (200 - 450 bar) and so is more common as in industrial method than as a lab technique.

The cobalt (or Ru) carbonyl hydride catalyst adds across the alkene double bond (or the alkene inserts into the Co-H bond), to form an intermediate with rearranges to a second intermediate which is reduced to aldehyde plus regenerated catalyst.